AGA Finds Lack of Evidence to Support Use of Probiotics to Treat Digestive Diseases

AGA Finds Lack of Evidence to Support Use of Probiotics to Treat Digestive Diseases

New AGA guideline finds that proof to assist use of probiotics to deal with digestive ailments is drastically missing, figuring out solely three scientific situations the place probiotics could profit sufferers.

It’s estimated that greater than 3.9 million American adults have taken some kind of probiotics, with many sufferers wanting to probiotics to enhance their gastrointestinal well being. Nonetheless, after an in depth evaluate of out there literature, the American Gastroenterological Affiliation (AGA) has launched new scientific pointers discovering that for many digestive situations there’s not sufficient proof to assist the use of probiotics. That is the primary scientific guideline to concentrate on probiotics throughout a number of GI ailments whereas additionally contemplating the impact of every single-strain or multi-strain formulation of probiotics independently as an alternative of grouping all of them below the only umbrella of “probiotics.” These pointers are printed in Gastroenterology, AGA’s official journal.

The rule of thumb helps use of sure probiotic formulations in three settings: for the prevention of Clostridioides difficile (C. difficile) an infection in adults and youngsters taking antibiotics, for the prevention of necrotizing enterocolitis in preterm, low birthweight infants, and for the administration of pouchitis, a complication of inflammatory bowel illness. There was inadequate proof to suggest probiotics for therapy of Crohn’s illness, ulcerative colitis, irritable bowel syndrome (IBS) and C. difficile an infection. For acute infectious gastroenteritis in youngsters, AGA recommends in opposition to the use of probiotics.

“Sufferers taking probiotics for Crohn’s, ulcerative colitis or IBS ought to contemplate stopping,” says guideline panel chair Grace L. Su from College of Michigan, Ann Arbor. “The dietary supplements could be pricey and there isn’t sufficient proof to show a profit or affirm lack of hurt. Speak along with your physician.”

Given widespread use and sometimes biased sources of info, it’s important that the general public have goal steerage in regards to the applicable use of and indications for probiotics. AGA employed the gold-standard for guideline improvement, GRADE methodology, to consider the out there proof on scientific efficacy of probiotics.

“Whereas our guideline does spotlight a couple of use instances for probiotics, it extra importantly underscores that the general public’s assumptions about the advantages of probiotics are usually not well-founded, and that there’s additionally a significant variation in outcomes primarily based on the formulation of the probiotic product,” says Dr. Su.

Key guideline suggestions:

Gastroenterologists ought to counsel the use of probiotics to their sufferers provided that there’s clear profit and may acknowledge that the consequences of probiotics are usually not species-specific, however strain- and combination-specific.?

Learn the AGA Institute pointers and technical evaluate on the position of probiotics within the administration of gastrointestinal ailments to evaluate the whole suggestions.



“AGA Medical Apply Tips on the Function of Probiotics within the Administration of Gastrointestinal Problems” by Grace L. Su, Cynthia W. Ko, Premysl Bercik, Yngve Falck-Ytter, Shahnaz Sultan, Adam V. Weizman and Rebecca L. Morgan, 9 June 2020, Gastroenterology.
DOI: 10.1053/j.gastro.2020.05.059

“AGA Technical Overview on the Function of Probiotics within the Administration of Gastrointestinal Problems” by Geoffrey A. Preidis, Adam V. Weizman, Purna C. Kashyap, Benham Sadeghirad and Rebecca L. Morgan, 9 June 2020, Gastroenterology.
DOI: 10.1053/j.gastro.2020.05.060


Probiotics have been round for a few years however have recently turn out to be extra in style. Probiotics live, microscopic (very small) organisms, together with sure micro organism and yeasts, which can be often present in meals or dietary dietary supplements. Some specialists imagine that probiotics could complement therapies, however don’t typically change them. Since there are a lot of sorts of probiotics with completely different strains and mixtures, it’s essential for sufferers to discuss to their physician earlier than beginning a probiotic.


AGA has recruited main specialists within the intestine microbiome and digestive well being to function the scientific advisory board for the AGA Heart for Intestine Microbiome Analysis & Training.

Leave a Reply

Your email address will not be published.

Back to top button