Tech News

Columbia Engineers Use DNA Nanotechnology to Build Tough 3D Nanomaterials

Mineralization of 3D lattice fashioned by DNA tetrahedra (about 30 nm) and gold nanoparticle into all-inorganic 3D silica-Au replicas with preserved structure. Credit score: Oleg Gang/Columbia Engineering

Columbia Engineers use DNA nanotechnology to create extremely resilient artificial nanoparticle-based supplies that may be processed by means of standard nanofabrication strategies.

Columbia Engineering researchers, working with Brookhaven Nationwide Laboratory, report in the present day that they’ve constructed designed nanoparticle-based 3D supplies that may face up to a vacuum, excessive temperatures, excessive strain, and excessive radiation. This new fabrication course of ends in strong and totally engineered nanoscale frameworks that not solely can accommodate quite a lot of purposeful nanoparticle sorts but additionally will be rapidly processed with standard nanofabrication strategies.

“These self-assembled nanoparticles-based supplies are so resilient that they might fly in area,” says Oleg Gang, professor of chemical engineering and of utilized physics and supplies science, who led the research revealed in the present day (March 19, 201) by Science Advances. “We had been in a position to transition 3D DNA-nanoparticle architectures from liquid state — and from being a pliable materials — to stable state, the place silica re-enforces DNA struts. This new materials totally maintains its unique framework structure of DNA-nanoparticle lattice, primarily making a 3D inorganic reproduction. This allowed us to discover — for the primary time — how these nanomaterials can battle harsh circumstances, how they kind, and what their properties are.”

Film visualizes a 3D reconstruction (utilizing FIB-SEM) of silicated DNA-nanoparticle lattice. The reconstruction reveals gold nanoparticles in lattice (silica construction will not be seen). The lattice rotates concerning the axis to visualize the construction from a number of instructions. Credit score: Oleg Gang/Columbia Engineering

Materials properties are completely different on the nanoscale and researchers have lengthy been exploring how to use these tiny supplies — 1,000 to 10,000 instances smaller than the thickness of a human hair — in every kind of functions, from making sensors for telephones to constructing quicker chips for laptops. Fabrication methods, nonetheless, have been difficult in realizing 3D nano-architectures. DNA nanotechnology allows the creation of complexly organized supplies from nanoparticles by means of self-assembly, however given the mushy and environment-dependent nature of DNA, such supplies may be secure below solely a slim vary of circumstances. In distinction, the newly fashioned supplies can now be utilized in a broad vary of functions the place these engineered buildings are required. Whereas standard nanofabrication excels in creating planar buildings, Gang’s new technique permits for fabrication of 3D nanomaterials which might be turning into important to so many digital, optical, and power functions.

Gang, who holds a joint appointment as group chief of the Gentle and Bio Nanomaterials Group at Brookhaven Lab’s Middle for Practical Nanomaterials, is on the forefront of DNA nanotechnology, which depends on folding DNA chain into desired two and three-dimensional nanostructures. These nanostructures turn into constructing blocks that may be programmed by way of Watson-Crick interactions to self-assemble into 3D architectures. His group designs and varieties these DNA nanostructures, integrates them with nanoparticles and directs the meeting of focused nanoparticle-based supplies. And, now, with this new method, the workforce can transition these supplies from being mushy and fragile to stable and strong.

Various kinds of nanoscale lattices fashioned with polyhedra DNA nano-frames (tetrahedra, cubes, and octahedra) and gold nanoparticle are mineralized with controllable silica coating thicknesses (from about 5nm to a full space-filling). Credit score: Oleg Gang/Columbia Engineering

This new research demonstrates an environment friendly technique for changing 3D DNA-nanoparticle lattices into silica replicas, whereas sustaining the topology of the interparticle connections by DNA struts and the integrity of the nanoparticle group. Silica works effectively as a result of it helps retain the nanostructure of the dad or mum DNA lattice, varieties a strong forged of the underlying DNA and doesn’t have an effect on nanoparticles preparations.

“The DNA in such lattices takes on the properties of silica,” says Aaron Michelson, a PhD scholar from Gang’s group. “It turns into secure in air and will be dried and permits for 3D nanoscale evaluation of the fabric for the primary time in actual area. Furthermore, silica supplies power and chemical stability, it’s low-cost and will be modified as wanted — it’s a really handy materials.”

To be taught extra concerning the properties of their nanostructures, the workforce uncovered the transformed to silica DNA-nanoparticles lattices to excessive circumstances: excessive temperatures above 1,0000C and excessive mechanical stresses over 8GPa (about 80,000 instances greater than environment strain, or 80 instances greater than on the deepest ocean place, the Mariana trench), and studied these processes in-situ. To gauge the buildings’ viability for functions and additional processing steps, the researchers additionally uncovered them to excessive doses of radiation and centered ion beams.

“Our evaluation of the applicability of those buildings to couple with conventional nanofabrication methods demonstrates a really strong platform for producing resilient nanomaterials by way of DNA-based approaches for locating their novel properties,” Gang notes. “It is a huge step ahead, as these particular properties imply that we will use our 3D nanomaterial meeting and nonetheless entry the total vary of standard supplies processing steps. This integration of novel and traditional nanofabrication strategies is required to obtain advances in mechanics, electronics, plasmonics, photonics, superconductivity, and power supplies.”

Collaborations primarily based on Gang’s work have already led to novel superconductivity and conversion of the silica to conductive and semiconductive media for additional processing. These embody an earlier research revealed by Nature Communications and one not too long ago revealed by Nano Letters. The researchers are additionally planning to modify the construction to make a broad vary of supplies with extremely fascinating mechanical and optical properties.

“Computer systems have been made with silicon for over 40 years,” Gang provides. “It took 4 many years to push the fabrication down to about 10 nm for planar buildings and units. Now we will make and assemble nanoobjects in a take a look at tube in a few hours with out costly instruments. Eight billion connections on a single lattice can now be orchestrated to self-assemble by means of nanoscale processes that we will engineer. Every connection could possibly be a transistor, a sensor, or an optical emitter — every is usually a bit of knowledge saved. Whereas Moore’s legislation is slowing, the programmability of DNA meeting approaches is there to carry us ahead for fixing issues in novel supplies and nanomanufacturing. Whereas this has been extraordinarily difficult for present strategies, it’s enormously necessary for rising applied sciences.”

Reference: “Resilient three-dimensional ordered architectures assembled from nanoparticles by DNA” by Pawel W. Majewski, Aaron Michelson, Marco A. L. Cordeiro, Cheng Tian, Chunli Ma, Kim Kisslinger, Ye Tian, Wenyan Liu, Eric A. Stach, Kevin G. Yager and Oleg Gang, 19 March 2021, Science Advances.
DOI: 10.1126/sciadv.abf0617

The research is titled “Resilient Three-Dimensional Ordered Architectures Assembled from Nanoparticles by DNA.”

Authors are: Pawel W. Majewski 1,2, Aaron Michelson3, Marco A. L. Cordeiro1, Cheng Tian1, Chunli Ma1, Kim Kisslinger1, Ye Tian1, Wenyan Liu1, Eric A. Stach3, Kevin G. Yager1, Oleg Gang1, 3, 5

The research was supported by US Division of Protection, Military Analysis Workplace, W911NF-19-1-0395. This analysis used sources of the Middle for Practical Nanomaterials and the Nationwide Synchrotron Gentle Supply II, that are U.S. DOE Workplace of Science Amenities, at Brookhaven Nationwide Laboratory below Contract No. DE-SC0012704. The DNA design work was supported by the US Division of Power, Workplace of Primary Power Sciences, Grant DE-SC0008772.

Back to top button

Adblock Detected

Please stop the adblocker for your browser to view this page.