Flavonoid-Rich Foods – Such As Apples, Berries, Dark Chocolate and Wine – Improve Blood Pressure Levels


Wine and darkish chocolate are wealthy in flavonoids.

Flavonoid-rich meals, together with berries, apples, pears and wine, seem to have a constructive impact on blood stress ranges, an affiliation that’s partially defined by traits of the intestine microbiome, in line with new analysis revealed right this moment in Hypertension, an American Coronary heart Affiliation journal.

“Our intestine microbiome performs a key position in metabolizing flavonoids to boost their cardioprotective results, and this research offers proof to counsel these blood pressure-lowering results are achievable with easy modifications to the day by day eating regimen,” mentioned lead investigator of the research Aedín Cassidy, Ph.D., chair and professor in vitamin and preventive medication on the Institute for World Meals Safety at Queen’s College in Belfast, Northern Eire.

Blackberries blueberries, and raspberries comprise flavonoids.

Flavonoids are compounds discovered naturally in fruits, greens and plant-based meals resembling tea, chocolate and wine, and have been proven in earlier analysis to supply quite a lot of well being advantages to the physique. Flavonoids are damaged down by the physique’s intestine microbiome—the micro organism discovered within the digestive tract. Current research discovered a hyperlink between intestine microbiota, the microorganisms within the human digestive tract, and heart problems (CVD), which is the main reason for demise worldwide. Intestine microbiota is very variable between people, and there are reported variations in intestine microbial compositions amongst folks with and with out CVD.

With elevated analysis suggesting flavonoids could scale back coronary heart illness threat, this research assessed the position of the intestine microbiome on the method. Researchers examined the affiliation between consuming flavonoid-rich meals with blood stress and intestine microbiome variety. The research additionally investigated how a lot variance inside the intestine microbiome may clarify the affiliation between consumption of flavonoid-rich meals and blood stress.

Tea is wealthy in flavonoids.

A gaggle of 904 adults between the ages of 25 and 82, 57% males from Germany’s PopGen biobank had been recruited for this research. (The PopGen biobank contains contributors from a community of seven biobanks in Northern Germany.) Researchers evaluated the contributors’ meals consumption, intestine microbiome and blood stress ranges along with different scientific and molecular phenotyping at common follow-up examinations.  

Contributors’ consumption of flavonoid-rich meals through the earlier 12 months was calculated from a self-reported meals questionnaire detailing the frequency and amount eaten of 112 meals. Flavonoid values had been assigned to meals in line with United States Division of Agriculture knowledge on flavonoid content material in meals.

Intestine microbiome for contributors was assessed by fecal bacterial DNA extracted from stool samples. After an in a single day quick, contributors’ blood stress ranges had been measured thrice in three-minute intervals after an preliminary five-minute relaxation interval. Researchers additionally collected contributors’ life-style data, together with intercourse, age, smoking standing, remedy use and bodily exercise, in addition to household historical past of coronary artery illness, the variety of day by day energy and fiber consumed, and every participant’s top and weight was measured to calculate BMI (physique mass index).

The evaluation of normal flavonoid consumption with intestine microbiome and blood stress ranges discovered:

“Our findings point out future trials ought to take a look at contributors in line with metabolic profile with a purpose to extra precisely research the roles of metabolism and the intestine microbiome in regulating the consequences of flavonoids on blood stress,” mentioned Cassidy. “A greater understanding of the extremely particular person variability of flavonoid metabolism may very properly clarify why some folks have larger cardiovascular safety advantages from flavonoid-rich meals than others.”

Whereas this research suggests potential advantages to consuming purple wine, the American Coronary heart Affiliation means that in case you don’t drink alcohol already, you shouldn’t begin. When you do drink, speak along with your physician about the advantages and dangers of consuming alcohol moderately. In accordance with a statement on dietary health by the American Coronary heart Affiliation, alcohol consumption is usually a part of a nutritious diet if consumed moderately (no multiple alcoholic drink per day for ladies and 2 alcohol drinks per day for males) and solely by nonpregnant girls and adults when there isn’t a threat to present well being circumstances, medication-alcohol interplay, or private security and work conditions.

The authors be aware that contributors for the research had been from the overall inhabitants, and the contributors had been unaware of the speculation. Nevertheless, residual or unmeasured confounding elements (resembling different well being circumstances or genetics) can result in bias, thus these findings can’t show a direct trigger and impact, though the researchers did conduct an in depth adjustment of their analyses for a variety of eating regimen and life-style elements. The authors famous the main focus of this research was on particular meals wealthy in flavonoids, not all meals and drinks with flavonoids.

Reference: 23 August 2021, Hypertension.
DOI: 10.1161/HYPERTENSIONAHA.121.17441

Co-authors are first writer Amy Jennings, Ph.D.; Manja Koch, Ph.D.; Corinna Bang, Ph.D.; Andre Franke, Ph.D.; and Wolfgang Lieb, M.D., M.Sc. The authors’ disclosures are listed within the manuscript.

The analysis was funded by grants from the German Analysis Basis and the German Federal Ministry of Training and Analysis. The PopGen biobank is supported by the German Federal Ministry of Training and Analysis and the Medical College of the College of Kiel.

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