“Holy Grail” – Hyperbaric Oxygen Treatments Reverse Aging Process in First Clinical Trial

“Holy Grail” – Hyperbaric Oxygen Treatments Reverse Aging Process in First Clinical Trial

Credit score: Shamir Medical Middle

Examine finds hyperbaric oxygen therapies halt the growing older of blood cells and reverses the growing older course of.

A brand new research from Tel Aviv College (TAU) and the Shamir Medical Middle in Israel signifies that hyperbaric oxygen therapies (HBOT) in wholesome growing older adults can cease the growing older of blood cells and reverse the growing older course of. Within the organic sense, the adults’ blood cells truly develop youthful because the therapies progress.

The researchers discovered {that a} distinctive protocol of therapies with high-pressure oxygen in a strain chamber can reverse two main processes related to growing older and its diseases: the shortening of telomeres (protecting areas positioned at each ends of each chromosome) and the buildup of outdated and malfunctioning cells in the physique. Specializing in immune cells containing DNA obtained from the individuals’ blood, the research found a lengthening of as much as 38% of the telomeres, in addition to a lower of as much as 37% in the presence of senescent cells.

The research was led by Professor Shai Efrati of the Sackler Faculty of Medication and the Sagol Faculty of Neuroscience at TAU and Founder and Director of the Sagol Middle of Hyperbaric Medication on the Shamir Medical Middle; and Dr. Amir Hadanny, Chief Medical Analysis Officer of the Sagol Middle for Hyperbaric Medication and Analysis on the Shamir Medical Middle. The scientific trial was performed as a part of a complete Israeli analysis program that targets growing older as a reversible situation.

The paper was revealed in Aging on November 18, 2020.

“For a few years our group has been engaged in hyperbaric analysis and remedy – therapies primarily based on protocols of publicity to high-pressure oxygen at varied concentrations inside a strain chamber,” Professor Efrati explains. “Our achievements over time included the development of mind features broken by age, stroke or mind harm.

“Within the present research we wished to look at the impression of HBOT on wholesome and unbiased growing older adults, and to find whether or not such therapies can decelerate, cease and even reverse the conventional growing older course of on the mobile stage.”

The researchers uncovered 35 wholesome people aged 64 or over to a sequence of 60 hyperbaric periods over a interval of 90 days. Every participant supplied blood samples earlier than, throughout and on the finish of the therapies in addition to a while after the sequence of therapies concluded. The researchers then analyzed varied immune cells in the blood and in contrast the outcomes.

The findings indicated that the therapies truly reversed the growing older course of in two of its main points: The telomeres on the ends of the chromosomes grew longer as an alternative of shorter, at a fee of 20%-38% for the completely different cell sorts; and the proportion of senescent cells in the general cell inhabitants was diminished considerably – by 11%-37% relying on cell sort.

“At present telomere shortening is taken into account the ‘Holy Grail’ of the biology of growing older,” Professor Efrati says. “Researchers all over the world are attempting to develop pharmacological and environmental interventions that allow telomere elongation.  Our HBOT protocol was capable of obtain this, proving that the growing older course of can in truth be reversed on the fundamental cellular-molecular stage.”

“Till now, interventions equivalent to way of life modifications and intense train had been proven to have some inhibiting impact on telomere shortening,” Dr. Hadanny provides. “However in our research, solely three months of HBOT had been capable of elongate telomeres at charges far past any at the moment obtainable interventions or way of life modifications. With this pioneering research, we’ve opened a door for additional analysis on the mobile impression of HBOT and its potential for reversing the growing older course of.”

Reference: “Hyperbaric oxygen remedy will increase telomere size and reduces immunosenescence in remoted blood cells: a potential trial” by Yafit Hachmo, Amir Hadanny, Ramzia Abu Hamed, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor and Shai Efrati, 18 November 2020, Aging.
DOI: 10.18632/aging.202188

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