A Rutgers-led staff has created higher biosensor expertise that will assist lead to secure stem cell therapies for treating Alzheimer’s and Parkinson’s ailments and different neurological problems.
The expertise, which incorporates a distinctive graphene and gold-based platform and high-tech imaging, displays the destiny of stem cells by detecting genetic materials (RNA) concerned in turning such cells into mind cells (neurons), according to a study within the journal Nano Letters.
Stem cells can turn out to be many differing types of cells. Because of this, stem cell remedy reveals promise for regenerative therapy of neurological problems corresponding to Alzheimer’s, Parkinson’s, stroke and spinal wire damage, with diseased cells needing substitute or restore. However characterizing stem cells and controlling their destiny have to be resolved earlier than they might be utilized in therapies. The formation of tumors and uncontrolled transformation of stem cells stay key boundaries.
“A essential problem is guaranteeing excessive sensitivity and accuracy in detecting biomarkers — indicators corresponding to modified genes or proteins — throughout the complicated stem cell microenvironment,” stated senior creator KiBum Lee, a professor within the Division of Chemistry and Chemical Biology within the Faculty of Arts and Sciences at Rutgers College-New Brunswick. “Our expertise, which took 4 years to develop, has demonstrated nice potential for analyzing a spread of interactions in stem cells.”
The staff’s distinctive biosensing platform consists of an array of ultrathin graphene layers and gold nanostructures. The platform, mixed with high-tech imaging (Raman spectroscopy), detects genes and characterizes totally different varieties of stem cells with larger reliability, selectivity, and sensitivity than right this moment’s biosensors.
The staff believes the expertise can profit a variety of functions. By creating easy, speedy and correct sensing platforms, Lee’s group goals to facilitate therapy of neurological problems by stem cell remedy.
Stem cells could turn out to be a renewable supply of substitute cells and tissues to deal with ailments together with macular degeneration, spinal wire damage, stroke, burns, coronary heart illness, diabetes, osteoarthritis, and rheumatoid arthritis, in accordance to the Nationwide Institutes of Well being.
Reference: “Twin-Enhanced Raman Scattering-Based mostly Characterization of Stem Cell Differentiation Utilizing Graphene-Plasmonic Hybrid Nanoarray” by Letao Yang, Jin-Ho Lee, Christopher Rathnam, Yannan Hou, Jeong-Woo Choi and Ki-Bum Lee, 30 October 2019, Nano Letters.
The examine’s co-lead authors are Letao Yang and Jin-Ho Lee, postdoctoral researchers in Lee’s group. Rutgers co-authors embrace doctoral college students Christopher Rathnam and Yannan Hou. A scientist at Sogang College in South Korea contributed to the examine.