New Evidence for Using Testosterone Therapy to Treat Obesity – Mean Weight Loss of 50 Pounds

New Evidence for Using Testosterone Therapy to Treat Obesity – Mean Weight Loss of 50 Pounds

New analysis masking 11 years of knowledge introduced at this yr’s European and Worldwide Congress on Obesity (ECOICO 2020) present that, in overweight males affected by hypogonadism (low testosterone), remedy with testosterone injections lowers their weight and improves a variety of different metabolic parameters. The analysis has been led by Dr. Farid Saad, Advisor, Medical Affairs Andrology, Bayer AG, Berlin, Germany, and Gulf Medical College College of Medication, Ajman, UAE, and colleagues.

Throughout the final decade, Dr Saad’s staff has introduced a number of items of analysis on the consequences of testosterone at different congresses, together with earlier years of the European Congress on Obesity. In these newest updates, they supply the latest knowledge on the long-term advantages, and likewise counsel testosterone remedy (TTh) may very well be an efficient various to bariatric (weight problems) surgical procedure.

The researchers collected knowledge from a German registry of males in 2004 from a urological follow based mostly in Bremerhaven. The boys all had useful hypogonadism (low testosterone with no identified natural trigger), and 471 of 773 males (61%) had weight problems. Of those males with weight problems, 276 males acquired TTh with testosterone undecanoate (TU) (a 1000 mg injection within the clinic each 3 months) for up to 11 years (T-group). The opposite 195 males opted towards TTh and served as controls (CTRL). Since injections have been administered within the physician’s workplace and documented, there was a 100% adherence to testosterone remedy. No sufferers dropped out of the research.

Modifications over time between teams have been in contrast and adjusted for age, weight, waist circumference, fasting glucose, blood stress, blood fat, and high quality of life to account for baseline variations between the 2 teams. The imply follow-up interval was 8.8 years for the T-group and eight.4 years for controls, and the typical age 60.6 years within the T-group and 63.5 years within the management group.

After 11 years of knowledge assortment within the registry (masking the interval 2004-19 with all sufferers having at the least 11 years of knowledge) weight (kg) decreased by a imply of 23kg within the T group (from 114kg to 89kg earlier than adjustment, and to 87 kg after adjustment for baseline age, waist circumference, weight, fasting glucose, systolic and diastolic blood stress, complete ldl cholesterol, HDL, LDL, triglycerides and the standard of life scale AMS). Conversely, imply weight elevated by 6kg within the management group. In share phrases, the outcomes have been comparable – with the T-group dropping a median of 20% body weight, whereas controls elevated by 6%.

Waist circumference decreased by a imply 13cm in these receiving testosterone remedy, and elevated by 7cm within the management group. Physique mass index (BMI) fell by 7.6 factors within the T-group (from 36.8 to 28.8 earlier than adjustment, and to 27.9 after adjustment), whereas it elevated by 2 factors within the controls. Measurements of visceral fats (inside fats held centrally and surrounding organs, and thought to trigger elevated well being dangers) have been additionally decrease within the T-group. The so-called visceral adiposity index (VAI) decreased by 2.7 factors within the T-group and elevated by 3.1 within the management teams.

There was additionally a big mortality distinction between teams: 21 sufferers (7.6%) died within the T-group and 63 (32.3%) within the management group. Greater than 1 / 4 of males (28%) within the management group had a coronary heart assault, and 53 (27.2%) a stroke. There have been no main cardiovascular occasions within the T-group. All of the deaths within the T-group have been associated to visitors and sport accidents and post-surgical infections.

A complete of 156 males (56.6%) within the T-group and 124 controls (63.6%) had sort 2 diabetes at baseline (outlined as glycated hemoglobin [HbA1c] of 6.5% or greater). An additional 43 sufferers (22.1%) developed T2D in the course of the research, that means virtually all (85%) of management sufferers had T2D after 11 years of follow-up. No further sufferers within the T-group developed sort 2 diabetes.

Dr. Saad says: “Lengthy-term testosterone remedy in hypogonadal males resulted in profound and sustained in weight reduction which can have contributed to reductions in mortality and cardiovascular occasions. Untreated males with hypogonadism gained weight.”

In different analysis introduced at this ECOICO 2020 congress, the researchers appeared particularly at males within the registry with weight problems class III, the best weight problems class making them most eligible for weight problems (bariatric) surgical procedure. A complete of 76 of the 773 males (9.8%) have been on this class. Of those, 59 males acquired testosterone remedy as outlined above, whereas the opposite 17 males opted towards this and served as controls. Comparable to the outcomes for the entire registry, weight decreased by a imply 30kg within the T group and elevated by 5kg in controls. BMI decreased by 10.0 factors within the T group and elevated by 3.0 factors in controls.

Dr. Saad says: “Lengthy-term testosterone remedy in males with hypogonadism and probably the most extreme degree of weight problems resulted in profound and sustained weight reduction in a magnitude comparable to that achieved with metabolic (weight problems) surgical procedure. Unwanted side effects and problems could also be in favor of testosterone remedy. We imagine testosterone remedy ought to be mentioned with sufferers instead to surgical procedure and ought to be thought of for male sufferers who can not endure surgical procedure.”

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