New Genetic Analysis Shows COVID-19 Coronavirus Did Not Spill Over From Pangolins (Scaly Anteaters)

New Genetic Analysis Shows COVID-19 Coronavirus Did Not Spill Over From Pangolins (Scaly Anteaters)

A Malay pangolin climbing a Lychee tree. Credit score: Jinping Chen

Mammals often called scaly anteaters are pure hosts of coronaviruses, however usually are not probably the direct supply of the latest outbreak in people, in keeping with a examine printed as we speak (Could 14, 2020) within the open-access journal PLOS Pathogens by Jinping Chen of the Guangdong Institute of Utilized Organic Assets, and colleagues. As famous by the authors, the large-scale surveillance of coronaviruses in these animals, referred to as pangolins, might enhance our understanding of the spectrum of coronaviruses circulating within the wild, and will assist stop and management rising infectious illnesses.

New Genetic Analysis Shows COVID-19 Coronavirus Did Not Spill Over From Pangolins (Scaly Anteaters)

Final December, an outbreak of the coronavirus illness (COVID-19) emerged in Wuhan, China. Latest research have proven that extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) — the virus that causes COVID-19 — might have originated in bats. However SARS-CoV-2 might have spilled over to people from one other intermediate host, and the supply of this virus continues to be unknown. To successfully management the illness and stop new spillovers, it’s vital to establish the animal origin of this newly rising coronavirus. Within the new examine, Chen and colleagues examined whether or not pangolins may very well be an intermediate host for SARS-CoV-2.

The researchers assembled the entire genome of a coronavirus recognized in two teams of sick Malayan pangolins. The outcomes counsel that the pangolin coronavirus is genetically related to SARS-CoV-2 and a gaggle of bat coronaviruses. However additional evaluation means that SARS-CoV-2 didn’t come up immediately from the pangolin coronavirus. Though this examine doesn’t assist the concept pangolins are an intermediate host immediately answerable for the emergence of SARS-CoV-2, it’s attainable that different coronaviruses may very well be circulating in pangolins. In line with the authors, wildlife conservation and restricted publicity to wildlife can be essential to reduce the danger that coronaviruses will spill over from wild animals to people.

The authors state, “Pangolins may very well be pure hosts of Betacoronaviruses with an unknown potential to contaminate people. Nevertheless, our examine doesn’t assist that SARS-CoV-2 developed immediately from the pangolin-CoV.”


Reference: “Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?” by Ping Liu, Jing-Zhe Jiang, Xiu-Feng Wan, Yan Hua, Linmiao Li, Jiabin Zhou, Xiaohu Wang, Fanghui Hou, Jing Chen, Jiejian Zou and Jinping Chen, 14 Could 2020, PLOS Pathogens.
DOI: 10.1371/journal.ppat.1008421

Funding: This undertaking was supported by wildlife illness monitoring and early warning system upkeep undertaking from Nationwide Forestry and Grassland Administration (2019072) to Chen JP, GDAS Particular Mission of Science and Expertise Improvement (grant quantity 2020GDASYL-20200103090, 2018GDASCX-0107) to Liu P.,Guangzhou Science Expertise and Innovation Fee (grant quantity 201804020080) to Chen JP, Pure Science Basis of China (grant quantity 31972847) to Jiang JZ, Guangzhou science and know-how undertaking (grant quantity 2019001) to Chen JP. The funders had no function in examine design, information assortment and evaluation, determination to publish, or preparation of the manuscript.

Competing Pursuits: The authors have declared that no competing pursuits exist.

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