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Researchers Identify a New Way to Suppress Lung Tumors
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Researchers Identify a New Way to Suppress Lung Tumors

Modifications in cell distribution for development selling proteins (EGFR;pink) when addition of sugar chains is decreased by the inhibitor, NGI-1. Proteins with out websites for addition of sugar chains (CRT; inexperienced) are unchanged.

A staff of researchers has recognized a new blocking mechanism that acts extra like a dimmer change and potently inhibits lung tumor cell development.

Lung most cancers cell development depends upon sure proteins that require the addition of sugar molecule chains to change into lively. Scientists have lengthy thought that the addition of those sugar chains is like an on or off change, and that blocking their addition could be dangerous. Now a Yale-led analysis staff has recognized a new blocking mechanism that acts extra like a dimmer change and potently inhibits lung tumor cell development.

Senior creator Joseph Contessa and his co-authors screened tons of of hundreds of chemical compounds to uncover a new inhibitor that reduces the addition of sugar chains with out harming non-tumor cells. Based mostly on this discovering, the analysis staff plans to take a look at the compound in preclinical research as a potential new technique for treating lung most cancers — the main reason for most cancers dying nationwide.

Publication: Cecilia Lopez-Sambrooks, et al., “Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells,” Nature Chemical Biology (2016) doi:10.1038/nchembio.2194

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